Recommend dosage is two (2) tablets taken three (3) times each day as a dietary supplement or as otherwise directed by a healthcare professional.

The kidneys, which are regulated by means of hormonal control, function to filter the blood and eliminate (excrete) metabolic waste products, including excess water, electrolytes and sodium, via the urine. They are also responsible for the excretion of many drug metabolites.

The three key hormones produced by the kidneys are calcitriol, erythropoeitin and renin. Calcitriol, 1,25 dihydroxycholecalciferol, the active form of Vitamin D, serves to regulate the absorption of calcium and phosphate, thus promoting the formation of strong bones. Erythropoietin (EPO) stimulates the bone marrow to produce red blood cells, while renin serves to regulate blood volume, thus playing an important role in the regulation of blood pressure. Additionally, the production of aldosterone by the adrenal glands is principally modulated by the renin-angiotensin system along with serum potassium. Experimental and clinical studies have demonstrated the importance of the renin-angiotensin system (RAS) and the pathogenesis of atherosclerosis, as well as the prognosis of coronary heart disease (CHD).